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The prolonged inflammatory state in chronic wounds also suppresses the function of key immune cells, including neutrophils and macrophages, by altering their cytokine profiles and impairing their ability to phagocytize and clear bacteria [45]

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Corticosteroid premedication and step-up dosing reduce the risk of severe CRS

It is the C-terminal sequence (positions 1113) of alpha-melanocyte-stimulating hormone (-MSH), a neuropeptide produced in the pituitary gland

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The treatment was well-tolerated, with no early discontinuations